The antiviral TPOXX is available for severe cases. See Get TPOXX

Cleveland Clinic recommends (7/6/22):

"If have monkeypox symptoms, there are over-the-counter medications that can help you feel better, including:

  • Pain relievers and fever reducers. Medicines like ibuprofen (Advil®, Motrin®) and acetaminophen (Tylenol®) can help you feel better.

  • Oatmeal baths. Soaking in a warm bath with colloidal oatmeal can relieve the dry, itchy feeling that comes with skin rashes.

  • Isolate yourself if you’re infected. Avoid contact with others until all your lesions have scabbed.

  • Cover single or local lesions. Use gauze or bandages to limit spread to others and the environment.

  • Take good care. It’s important to stay home and rest when you’re sick, wear a mask around others and drink plenty of fluids.

  • Avoid contact with pets (especially rodents)."

"There are no treatments specifically for monkeypox virus infections. However, monkeypox and smallpox viruses are genetically similar, which means that antiviral drugs and vaccines developed to protect against smallpox may be used to prevent and treat monkeypox virus infections.

Antivirals, such as tecovirimat (TPOXX), may be recommended for people who are more likely to get severely ill, like patients with weakened immune systems.

If you have symptoms of monkeypox, you should talk to your healthcare provider, even if you don’t think you had contact with someone who has monkeypox."

(CDC 7/6/22 )

Gabapentin is mentioned on Dan Savage's monkeypox podcast

"So You Got Monkeypox" doc (different maintainer than this site), crowdsourced information, below:

So You Got Monkeypox